A recent article published in the Journal of Pediatric Gastroenterology and Nutrition reported on the international guidelines on the management of functional constipation in children. It was stated that polyethylene glycol (PEG) is recommended as the laxative of first choice in the treatment of functional constipation in children, both, for disimpaction and for maintenance treatment. It was elaborated that PEG acts as an osmotic laxative and its efficacy is dose dependent. Additionally, PEG is highly effective, has a good safety profile, and is well tolerated by children. While only minor adverse events have been reported with the use of PEG. In summary it was stated that overall, the use of PEG in children has been found to be safe. Furthermore, PG+E is preferable for preventing water and electrolyte imbalances in children.